Syntheses of Pentazocine

Cutaneous complications of pentazocine abuse.

Pentazocine : a Study of Its Sedative Properties

The sedative effects of pentazocine 50 mg given orally have been studied in 100 healthy gynaecological patients using a standard scoring system. It was found that pentazocine produced mild sedation which was not significantly greater than that produced by a placebo in the numbers studied. The incidence of complications was low and while there was a higher incidence of postoperative nausea and v...

Antinociceptive Effect of Pentazocine in Diabetic Rats

Aim: The objective of the current study is to investigate the antinoceptive effect of Pentazocineon streptozotocininduced diabetic rats. Methods: Diabetes mellitus was induced by using streptozotocin, dose of 50mg/kg body weight through lateral tail vein injection. After 48 hours, rat with blood glucose range of 200–300mg were used for experiment. NPH – insulin was given by subcutaneous injecti...

Detection of pentazocine and tripelennamine in urine.

Pentazocine and tripelennamine can be identified in urine as a part of routine screening for drug abuse. Pentazocine, pentazocine hydrate, and tripelennamine can be detected by thin-layer chromatography of chloroform/isopropanol extracts of heat- and acid-hydrolyzed urine. Gas chromatography is used for confirmation. Gas chromatographic/mass spectrometric studies (chemical ionization mode) show...

NITROIMIDAZOLES XI [I]. SYNTHESES OF DISUBSTITUTED NITROIMIDAZOLYLQUINOLINES

Reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. Substituted-2-(l-methyl-5-nitro-2-imidazo1yl)-4.- methyl-(or phenyl-) quinolines (14) were prepared through the reaction of 2- acetyl-5-nitro-1-methy...